Updates in progress!

  • ERK plays a conserved dominant role in pancreas cancer cell EMT heterogeneity driven by diverse growth factors and chemotherapies

    Michelle C Barbeau, Brooke A Brown, Sara J Adair, Todd W Bauer, Matthew J Lazzara, bioRxiv

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  • Hypoxia-induced histone methylation and NF-κB activation in pancreas cancer fibroblasts promote EMT-supportive growth factor secretion

    Karl M. Kowalewski, Sara J. Adair, Anne Talkington, Jason J. Wieder, Jason R. Pitarresi, Kia Perez-Vale, Britney Chu, Sepideh Dolatshahi, Rosalie Sears, Ben Z. Stanger, Todd W. Bauer, Matthew J. Lazzara, bioRxiv

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  • Systems Biology of the Cancer Cell Item

    Janes KA and Lazzara MJ. Annual Review of Biomedical Engineering. Online ahead of print, 2024.

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  • A Histone Methylation-MAPK Signaling Axis Drives Durable Epithelial-Mesenchymal Transition in Hypoxic Pancreatic Cancer

    Brown BA, Myers PJ, Adair SJ, Pitarresi JR, Sah-Teli SK, Campbell LA, Hart WS, Barbeau MC, Leong K, Seyler N, Kane W, Lee KE, Stelow E, Simon MC, Koivunen P, Bauer T, Stanger BZ, Lazzara MJ. Cancer Research 84:1764-1780, 2024.

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  • Divergent transcriptomic signatures from putative mesenchymal stimuli in glioblastoma cells

    Hart WS, Myers PJ, Purow BW, Lazzara MJ. Cancer Gene Therapy 31: 851-860, 2024.

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  • Understanding how transmembrane domains regulate interactions between human BST-2 and the SARS-CoV-2 accessory protein ORF7a

    Mann MA, Hsieh M-K, Tang JD, Hart WS, Lazzara MJ, Klauda JB, Berger BW. Biochim Biophys Acta Biomembr 1865: 184174, 2023.

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  • Agent-Based Model of Multicellular Spheroid Pattern Formation Driven by Synthetic Cell Adhesion Signaling Circuits

    Sivakumar N, Warner HV, Peirce SM, Lazzara MJ. PLOS Computational Biology 18: e1010701, 2022.

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  • Mechanistic and data-driven models of cell signaling: Tools for fundamental discovery and rational design of therapy.

    Myers PJ, Lee SH, Lazzara MJ. Current Opinion in Systems Biology 28: 100349, 2021.

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  • Mathematical Model Predicts that Acceleration of Diabetic Wound Healing is Dependent on Spatial Distribution of VEGF-A mRNA (AZD8601)

    Rikard SM, Myers PJ, Bruce AC, Wågberg M, Almquist J, Gennemark P, Fritsche-Danielson R, Hansson K, Lazzara MJ, Peirce SM. Cellular and Molecular Bioengineering 14, 321–338, 2021.

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  • Data-driven computational modeling identifies determinants of glioblastoma response to SHP2 inhibition

    Day EK, Zhong Q, Purow B, Lazzara MJ. Cancer Research 81: 2056-2070, 2021.

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  • ERK-dependent suicide gene therapy for selective targeting of RTK/RAS-driven cancers

    Day EK, Campbell AM, Pandolf A, Rogerson T, Zhong T, Xiao A, Purow B, Lazzara MJ. Molecular Therapy 29: 1585-1601, 2021.

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  • Calcium-stimulated disassembly of focal adhesions mediated by an ORP3-IQSec1 complex

    D'Souza RS, Lim JY, Turgut A, Servage K, Zhang J, Orth K, Sosale N, Lazzara M, Allegood J, Casanova JE. Elife 9: E54113, 2020.

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  • Glioblastoma resistance to EGFR and MET inhibition arises via FGFR/SPRY2 bypass signaling

    Day EK, Sosale NG, Xiao A, Zhong Q, Purow B, Lazzara MJ. Cell Reports 30: 3383-3396, 2020.

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  • Effects of proximal tubule shortening on protein excretion in a Lowe syndrome model

    Gliozzi ML, Espiritu EB, Shipman KE, Rbaibi Y, Long KR, Roy N, Duncan AW, Lazzara MJ, Hukriede NA, Baty CJ, Weisz OA. Journal of the American Society of Nephrology 31: 67-83, 2020.

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  • Disrupting the transmembrane domain-mediated oligomerization of protein tyrosine phosphatase J inhibits EGFR-driven cancer cell phenotypes

    Bloch E, Sikorski EL, Pontoriero D, Day EK, Berger BW, Lazzara MJ, Thévenin D. Journal of Biological Chemistry 294: 18796-18806, 2019.

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  • Multiscale computational models of cancer

    Warner HV, Sivakumar N, Peirce SM, Lazzara MJ. Current Opinion in Biomedical Engineering 11: 137-144, 2019.

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  • Localization dynamics of endogneous fluorescently-labeled RAF1 in EGF-stimulated cells

    Surve SV, Myers PJ, Clayton SA, Watkins SC, Lazzara MJ, and Sorkin A. Molecular Biology of the Cell 30:506-523, 2019.

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  • An engineering design approach to systems biology

    Janes KA, Chandran PL, Ford RM, Lazzara MJ, Papin JA, Peirce SM, Saucerman JJ, and Lauffenburger DA. Integrative Biology 9: 574-583, 2017.

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  • Cell Signaling Regulation by Protein Phosphorylation: A Multivariate, Heterogeneous, and Context-dependent Process

    Day EK, Sosale NG, and Lazzara MJ. Current Opinion in Biotechnology 40: 185-192, 2016.

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  • EGF augments TGFβ-induced epithelial-mesenchymal transition by promoting SHP2 binding to GAB1

    Buonato JM, Lan IS, and Lazzara MJ. Journal of Cell Science 128: 3898-3909, 2015.

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  • EGFR-activated Src family kinases maintain GAB1-SHP2 complexes distal from EGFR

    Furcht CM, Buonato JM, and Lazzara MJ. Science Signaling 8: RA46, 2015.

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  • Sprouty2 drives drug resistance and proliferation in glioblastoma

    Walsh AM, Kapoor GS, Buonato JM, Mathew LK, Bi Y, Davuluri RV, Simon MC, O’Rourke DM, and Lazzara MJ. Molecular Cancer Research 13: 1227-37, 2015.

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  • Identifying determinants of EGFR-targeted therapeutic biochemical efficacy using computational modeling

    Monast CS and Lazzara MJ. CPT Pharmacometrics and Systems Pharmacology 3: E141, 2014.

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  • Multivariate signaling regulation by SHP2 differentially controls proliferation and therapeutic response in glioma cells

    Furcht CM, Buonato JM, Skuli N. Mathew LK, Munoz Rojas A, Simon MC, and Lazzara MJ. Journal of Cell Science 127: 3555-67, 2014.

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  • P53Ψ is a transcriptionally inactive p53 isoform able to reprogram cells toward a metastatic-like state.

    Senturk S, Yao Z, Camiolo M, Stiles B, Rathod T, Walsh AM, Nemajerova A, Lazzara MJ, Alttorki NK, Krainer A, Moll UM, Lowe SW, Cartegni L, and Sordella R. PNAS 111: E3287-96, 2014.

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  • Differential parsing of EGFR endocytic flux among parallel internalization pathways in lung cancer cells with EGFR-activating mutations

    Walsh AM and Lazzara MJ. Integrative Biology 6: 312-323, 2014.

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  • ERK1/2 blockade prevents epithelial-mesenchymal transition and promotes cellular sensitivity to EGFR inhibition in lung cancer cells

    Buonato JM and Lazzara MJ. Cancer Research 74: 309-319, 2014.

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  • Exocyst Sec10 protects renal tubule cells from injury by EGFR/MAPK activation and effects on endocytosis

    Fogelgren B, Zuo Z, Buonato J, Vasilyev A, Baek J-I, Choi SY, Chacon-Heszele MF, Palmyre A, Polgar N, Dummond IA, Park KM, Lazzara MJ, and Lipschutz J. American Journal of Physiology Renal Physiology 307: F1334-41, 2014.

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  • Diversity in dimerization topologies enables differential control of receptor tyrosine kinase phosphorylation dynamics

    Monast CS and Lazzara MJ. Cellular and Molecular Bioengineering 7: 86-98, 2014.

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  • Regulation of EGFR trafficking and cell signaling by Sprouty2 and MIG6 in lung cancer cells

    Walsh AM and Lazzara MJ. Journal of Cell Science 126: 4339-4348, 2013.

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  • Quantitative modeling approaches for understanding the roles of protein phosphatases in cell signaling regulation: Applications to metabolism

    Lazzara MJ. Protein Tyrosine Phosphtase Control of Metabolism, 2013.

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  • Aberrant ERK signaling causes resistance to EGFR kinase inhibitors

    Ercan D, Xu C, Yanagita M, Monast CS, Pratila CA, Boronat JM, Shimamura T, Rogers A, Repellin C, Capelletti M, Goetz E, Letai A, Garraway LA, Lazzara MJ, Rosen N, Gray NS, Wing K-K, and Jänne PA. Cancer Discovery 2: 934-947, 2012.

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  • Diminished functional role and altered localization of SHP2 in non-small cell lung cancer cells with EGFR-activating mutations

    Furcht CM, Muñoz Rojas AR, Nihalani D, and Lazzara MJ. Oncogene 32: 2346-2355, 2013.

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  • Computational model of the regulation of EGFR by protein tyrosine phosphatases

    Monast CS, Furcht CM, and Lazzara MJ. Biophysical Journal 102: 2012-2021, 2012.

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  • Motor protein Myo1c is a podocyte protein that facilitates the transport of slit diaphragm protein Neph1 to podocyte membrane

    Arif E, Wagner MC, Johnstone D, Wong H, George B, Pruthi P, Lazzara MJ, and Nihalani D. Molecular Cell Biology 10: 2134-50, 2011.

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  • Incomplete SHP2-mediated ERK activation contributes to gefitinib sensitivity of lung cancer cells with EGFR-activation mutations

    Lazzara MJ, Lane K, Chan R, Jasper P, Yaffe M, Sorger PK, Jacks T, Neel BG, and Lauffenburger DA. Cancer Research 70: 3843-50, 2010.

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  • Quantitative modeling perspectives on the ErbB system of cell regulatory processes

    Lazzara MJ and Lauffenburger DA. Experimental Cell Research 315: 717-725, 2009.

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  • Model of albumin reabsorption in the proximal tubule

    Lazzara MJ and Deen WM. American Journal of Physiology Renal Physiology 292: F430-439, 2007.

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  • Decreased internalization of ErbB1 mutants in lung cancer is linked with a mechanism conferring sensitivity to gefitinib

    Hendriks BH, Griffiths GJ, Benson R, Kenyon D, Lazzara M, Swinton J, Beck S, Hickinson M, Beusmans JM, Lauffenburger DA, DeGraaf D. Systems Biology 153:457-66, 2006.

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  • The effects of flow rate on membrane capacity: Development and application of adsorptive membrane fouling models

    Bolton GR, Boesch AW, and Lazzara MJ. Journal of Membrane Science 279: 625-634, 2006.

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  • The fiber-coating model of biopharmaceutical depth filtration

    Bolton GR, LaCasse D, Lazzara MJ, and Kuriyel R. AIChE Journal 51: 2978-2987, 2005.

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  • Glomerular filtration of albumin: How small is the sieving coefficient?

    Deen WM and Lazzara MJ. Kidney International 66: S63-S64, 2004.

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  • Protein partitioning driven by excluded-volume interactions in an aqueous nonionic micellar-gel system

    van Roosmalen D, Lazzara MJ, van den Broeke LJP, Keurentjes JTF, and Blankschtein D. Biotechnology and Bioengineering 87: 695-703, 2004.

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  • Effects of concentration on the partitioning of macromolecule mixtures in agarose gels

    Lazzara MJ and Deen WM. Journal of Colloid and Interface Science 272: 288-297, 2004.

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  • Structural determinants of glomerular permeability

    Deen WM, Lazzara MJ, and Myers BD. American Journal of Physiology Renal Physiology 281: F579-F596, 2001.

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  • Effects of plasma proteins on the sieving of tracer macromolecules in glomerular basement membrane

    Lazzara MJ and Deen WM. American Journal of Physiology Renal Physiology 281: F860-F868, 2001.

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  • Effects of multi-solute steric interactions on membrane partition coefficients

    Lazzara MJ, Blankschtein D, and Deen WM. Journal of Colloid and Interface Science 226: 112-122, 2000.

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